Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Target K_i: 1.7 nM against protein kinase A

Primary TargetPKA

General description

A potent and competitive inhibitor of PKA (K_i = 1.7 nM).

A potent and competitive inhibitor of protein kinase A (K_i = 1.7 nM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Glass, D.B., et al. 1989. J. Biol. Chem. 264, 8802.Kemp, B.E., et al. 1988. Methods Enzymol.159, 173.

Packaging

1 mg in Plastic ampoule

Yes

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂

Warning

Toxicity: Standard Handling (A)